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Naegleria Flashcards

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1023830599Naegleriaare free living aerobic amoebae with several life stages, live in soil, freshwater. reproduce by binary fission of trophozoite
1023830600Naegleria life stages1.trophozoite-motile, feeding stage, food cups, favorable conditions, move using psuedopodium 2. flagellate stage- have flagella and basal bodies, dependent of transcription and translation 3. cyst- quiescent, resistant, infective, anoxia, pH changes, dessication
1023830601Naegleria Pathogenesisopportunistic => colonization of nasal mucosa asymptomatic => colonization can result in primary amoebic meningoencephalitis => host response via complement
1023830602pathogenic specieshumans- N. fowleri mice- N. australiensis, N. lovaniensis
1023830603non-pathogenic speciesN. gruberi, N. jadini, N. thorntoni
1023830604Naegleria symptomsfrontal lobe headache, stiff neck, altered taste and smell, and fever
1023830605Naegleria signspurulent, bloody CSF with elevated PMNs, RBC, and amoebae nasal discharge, increase in protein, decrease in glucose, Kernig's sign
1023830606Naegleria pathologytrophozoites within tissue not cysts. stain saline preps with Iodine- presenceo f amoebae is diagnostic. differential diagnosis- Acanthoamoeba, Balamuthia
1023830607Naegleria treatmentamphotericin B, Miconazole, and rifampicin F together corifungin- new macrolide Miltefosine (investigational)- used for leishmaniasis. efficacy vs amoeba in lab (Naegleria, Balamuthia mandrillis, and Acanthoamoeba
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