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Vitamin B12 Deficiency and Megaloblastic Anemia Flashcards

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3099917839Methylenetetrahydrofolate reductaseWhich enzyme catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is a cosubstrate for homocysteine remethylation to methionine?0
3099933722What is the most common genetic cause of hyperhomocysteinemia?Genetic defects in 5-MTHF reductase.1
3099976786What are the functions of methionine?It is an essential amino acid containing sulfur that acts as a chelating agent for heavy metals, a lipotropin agent to prevent fat buildup in the liver, a protector of cells against aging, and absorbs selenium and zinc.2
3100027571How does methionine function in translation?The amino acid that is coded by the initiation codon AUG.3
3100046369CyanocobalaminWhat form of Vitamin B12 is utilized in nutritional supplements?4
3100058875AmblyopiaWhat is the term for eye nerve damage that occurs if a B12 deficiency cannot be treated with cyanocobalamin supplements?5
3100080036How can allergies be treated with Vitamin B12?Can be treated with vitamin B12 supplements, which stimulates TH1 suppressor cells which reduce the production of IgE.6
3100101641List 6 Vitamin B12 diagnostic tests:VB12 level, homocysteine, MMA, MTHFR, FIGLU, Schilling's test (obsolete).7
3100154900What are some typical Vitamin B12 deficiency laboratory findings?Low serum iron, High serum LDH, Increased MMA or homocysteine, hyperhsegmented neutrophils, high MCV, severe pancytopenia, giant bands.8
3100272742What are some typical Vitamin B12 deficiency chemistry findings?Decreased serum haptoglobin binding capacity, normal folate, increased serum iron, increased transferrin saturation, LDH increased, increased unconjugated bilirubin, elevated methylmalonic acid and homocysteine, decreased uric acid.9
3100334560What causes pernicious anemia?Autoimmune disease against Intrinsic Factor or parietal cells of the stomach. Intrinsic factor is crucial for normal absorption of vitamin B12.10

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