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Vitamin B12 deficiency Flashcards

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5703278503Vit. B12- Cofactor in conversion of homocysteine to methionine - Cofactor in conversion of methyl malonyl- CoA to succinyl CoA - The mechanism of n.s. damage in B12 def. is unclear, thought to be impaired in myelin synthesis0
5703309463Causes- Malabsorption of vit. B12 reflecting lack of intrinsic factor - after gastrectomy - fish tapeworm - celiac disease - gastric malignancy - thyrotoxicosis - extreme vegetarian diet1
5703332530Clinical syndromes- Subacute combined degeneration of the spinal cord - Polyneuropathy - Dementia / encephalopathy ** Roomberg = positive Cerebellar syndrome Optic neuritis2
5703379877Diagnosis- Serum vit. B12 - Complete blood count (75% have megaloblastic anemia)3
5703388600Supplementation1000 micrograms daily for a week 1000 micrograms weekly for a month 1000 micrograms monthly for life4
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