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Vitamin B12 Flashcards

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9560362672Other nameCobalamin ; big and many other forms0
9560367924Properties- High molecular weight, red crystalline - Occurs in complexes with protein in animal food - Increases biological value of protein - Antibiotics increase growth of animals 15-20% by inhibiting growth of microogranicsms that destroy B12 - Contains cobalt; for humans1
9560415388Absorption in stomachHCl and Intrinsic factor HCL acid splits of B12 from protein complexes in food and salivary protein before denaturing it - elderly may produce less acid Then binds for R factor Splits by proteases and rebinds to Intrinsic Factor2
9560463602Where do most deficiencies come from?Absoprtion problems, not diet problems3
9560470483FunctionsInvolved in transfer of methyl groups - removes a methyl to activate folate coenzym THF - Folate donates methyl to activate Vitamin B12 General growth and anemia prevention Protein and fat metabolism DNA formation4
9560485443Deficiencies-Pernicious anemia (same as macrocytic with folate, but diff name bc B12) - Fatigue and weakness - Irreversible degeneration of nervous system - Can be mistaken for dimentia - High does levels given in brain atrophy - Abnormal blood lipids; coating in tongue5
9560509481Requirements2.4 ug ; most diets contain 30-70 ug; most potent6
9560513643Food sourcesall animal foods; bioactive supplement7

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