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Dominance

Hardy Weinberg Practice Problems

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PERIOD 4 Case 1: Ideal H-W ? Surviving Genotypes ? AA Aa aa Parental ? 22 ? F1 4 14 4 F2 8 9 5 F3 8 12 2 F4 7 14 1 F5 10 7 5 Freq. of genotypes Freq. of alleles Gen. # p2 (AA) 2pq (Aa) q2 (aa) p (A) q (a) Parental (H-W hypo.) F5 (H-W hypo) F5 (actual) Case 2: Selection against Homozygous Recessive ? Surviving Genotypes ? AA Aa aa Parental ? 22 ? F1 8 14 0 F2 15 7 0 F3 15 7 0 F4 13 9 0 F5 12 10 0 Freq. of genotypes Freq. of alleles Gen. # p2 (AA) 2pq (Aa) q2 (aa) p (A) q (a) Parental (H-W hypo.) F5 (H-W hypo) F5 (actual) Case 3: Heterozygous Advantage ? Surviving Genotypes ?

chapter 14 notes

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Chapter 14 Mendel and the Gene Idea Overview: Drawing from the Deck of Genes What genetic principles account for the transmission of traits from parents to offspring? One possible explanation of heredity is a ?blending? hypothesis The idea that genetic material contributed by two parents mixes in a manner analogous to the way blue and yellow paints blend to make green An alternative to the blending model is the ?particulate? hypothesis of inheritance: the gene idea Parents pass on discrete heritable units, genes Gregor Mendel Documented a particulate mechanism of inheritance through his experiments with garden peas Figure 14.1 Concept 14.1: Mendel used the scientific approach to identify two laws of inheritance Mendel discovered the basic principles of heredity

Genetics 2

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Mendel's Genetics ? Hybridized domesticated horses For thousands of years farmers and herders have been selectively breeding their plants and animals to produce more useful?hybrids?. ? It was somewhat of a hit or miss process since the actual mechanisms governing inheritance were unknown.? Knowledge of these genetic mechanisms finally came as a result of careful laboratory breeding experiments carried out over the last century and a half. ? ? Gregor Mendel???? 1822-1884???

Genetics 1

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Mendelian Genetics All Materials ? Cmassengale? 1862 1868 1880 Genetic Terminology: Trait?- any characteristic that can be passed from parent to offspring Heredity?- passing of traits from parent to offspring Genetics?- study of heredity Alleles?- two forms of a gene (dominant & recessive) Dominant?- stronger of two genes expressed in the hybrid; represented by a?capital letter (R) Recessive?- gene that shows up less often in a cross; represented by a?lowercase letter (r) Genotype?- gene combination for a trait (e.g. RR, Rr, rr) Phenotype?- the physical feature resulting from a genotype (e.g. tall, short) Homozygous?genotype - gene combination involving 2 dominant or 2 recessive genes (e.g. RR or rr); also called?pure?

Patterns of Heredity

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Patterns of Heredity and Human Genetics Mendelian Inheritance of Human Traits Pedigree: a graphic representation of genetic inheritance A pedigree uses symbols that identify males and females, family relationships, individuals affected by a trait being studied. Carrier: an individual who carries a recessive trait that is not expressed (heterozygous) Simple Recessive Heredity Most genetic disorders are caused by recessive alleles. Cystic Fibrosis Most common fatal genetic disorder in US among people of European descent (1/28 carry, 1/2500 affected) Cells in respiratory and digestive system produce huge quantities of mucus Catch infections easily and suffocate Usually die before reach 20?s Tay-Sachs Disease

linkage chi-square test

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1 LECTURE: Linkage & Chi-square test Linkage & Chi-squared Test Outline and Objective 2 ? Accounting for disruptions in expected Mendelian ratios ? Application of the Chi-square test ? Objective: At the end of this lesson you should be able to: 1. Define the term linked gene 2. Differentiate between results obtained from linked genes and non-linked genes in dihybrid crosses 3. Write a null hypothesis 4. Apply the chi-squared test to results observed from crosses LECTURE: Linkage & Chi-square test 3 Review ?We have been looking so far at inheritance of genes on different chromosomes. ? Since humans for example, have thousands of traits, each chromosome must carry a large number of genes.

Chapter 11- Complex Inheritance and Human Heredity

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Chapter 11: Complex Inheritance and Human Heredity RECESSIVE GENETIC DISORDERS -A recessive trait that is expressed when the individual is homozygous recessive for the trait CYSTIC FIBROSIS -Affects the mucus-producing glands, digestive enzymes, and sweat glands ALBINISM -Caused by altered genes, resulting in the absence of melanin in hair and eyes TAY-SACHS DISEASE -Gangliosides (fatty acids) accumulate in the brain, inflating brain nerve cells and causing mental deterioration GALACTOSEMIA -Recssive genetic disorder characterized by the inability of the body to digest galactose DOMINANT GENETIC DISORDERS -Huntington's Disease affects the nervous system -Achondroplasia is a genetic condition that causes small body size and limbs that are comparatively short

Campbell Biology 9th Edition Chapters 14-18 Study Guide

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Chapters 14 and 15 Gregor Mendel Studied traits that occur in distinct forms Developed true-breeding varieties When bred amongst themselves, by self-fertilization, these plants produced offspring identical to the parent for that trait No variation in that one trait Used mathematical analysis in his studies Findings related mainly to plants, not humans Definitions Gametes: reproductive cells produced by sexually-reproducing organisms Two types: Male gametes=sperm In plants: contained in pollen Female gametes=eggs In plants, contained in ovules, which mature to seeds when fertilized Ovules contained in carpels Fertilization Fertilization: fusion of egg and sperm Self-fertilized: fusion of sperm and egg from same plant

Chapter 10- Sexual Reproduction and Genetics Cont.

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Chapter 10: Sexual Reproduction and Genetics Cont. MENDELIAN GENETICS -The parent generation known as the P generation -The offspring of this P cross is calle dthe first filial (F1) generation -The second filial (F2) generation is the offspring of the F1 cross -Mendel studied seven different traits: -Seed or pea color -Flower color -Seed pod color -Seed shape or texture -Seed pod shape -Stem length -Flower position GENES IN PAIRS -Allele -An alternative form of a single gene passed form generation to generation -Dominant -Recessive DOMINANCE -An organism with two of the same alleles for a particular trait is homozygous -An organism with two different alleles for a particular trait is heterozygous GENOTYPE AND PHENOTYPE

Bio_160_Lecture3

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Inheritance and DNA Cellular Basis of Reproduction & Inheritance ? Chapter 8 The cell cycle multiplies cells and consists of two major phases Figure 8.5 ? The stages of cell division Figure 8.6 (Part 1) Figure 8.6 (Part 2) Cytokinesis differs for plant and animal cells Figure 8.7A The binding of growth factors to specific receptors on the plasma membrane is usually necessary for cell division. Control systemG1 S G2M G1 checkpoint Plasma membrane Growth factor Receptor protein Relay proteins Signal transduction pathway Figure 8.9B ? Cancer cells divide excessively to form masses of cells called tumors ?Malignant tumors can invade other tissues Tumor Glandular tissue A tumor grows from a single cancer cell. Cancer cells invade

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