| 968363030 | Dicentric Chromosome | A chromosome having two centromeres, which is usually unstable. | | 0 |
| 968363031 | Connexin | Protein involved in forming gap junctions. | | 1 |
| 968402443 | The Pasteur Effect | An effect by which aerating yeast cell broth (and thus introducing more O2) caused the rate of growth of yeast to rise while the rate of fermentation decreased. This is due to the yeast switching from an anaerobic metabolism to an aerobic mechanism, generating energy much more efficiently. | | 2 |
| 968402444 | Mitochondrial Ribosomes | Mitochondria do contain ribosomes, and this is evidence for the endosymbiont hypothesis because they are inhibited by the same kinds of drugs that inhibit prokaryote ribosomes. | | 3 |
| 968402445 | Molar Extinction Coefficient (Also known as the Molar Absorption Coefficient) | Measures how strongly a liquid absorbs light at a specific wavelength. Units of the MAC are 1/M cm or L/M cm | | 4 |
| 968402446 | Nicotinic acetylcholine receptors | A ligand gated ion channel in neurons that can not only be opened by acetylcholine but also nicotine. In this they differ from Muscarinic acetylcholine receptors | | 5 |
| 968402447 | Muscarinic acetylcholine receptors | A GPCR located in neuronal cell walls which responds to the fungal metabolite muscarine. | | 6 |
| 968478490 | The glyoxylate cycle | A modified version of the TCA cycle which occurs only in plants, bacteria, protists and fungi. It is an anabolic pathway which convert Acetyl-CoA to succinate for use in carbohydrate synthesis. In vertebrates, two missing enzymes, malate synthase and isocitrate lyase are missing and thus this pathway foes not typically function. | | 7 |
| 968478491 | Urea Cycle (also known as the ornithine cycle) | Produces Urea (NH2)2CO from ammonia (NH3). Takes place in liver and kidneys. Smooth endo reticulum. | | 8 |
| 968478492 | FRET (Fluorescence Resonance Energy Transfer) | A mechanism involving transfer of energy between two chromophores. Can be used in vivo to study interactions between two proteins. Transfer involves the lower energy chromophore emitting light. Can also be used to measure distance between domains on a protein. Incidence of FRET decays with the sixth power of distance between two chromophores. | | 9 |
| 968478493 | epinephrine/isoproterenol/propranolol | All bind to Beta Adrenergic Receptors (which are GPCR receptors found in cell membranes) Activates fight or flight response. Epi is ligand, Iso is an agonist, and Propranolol is an antagonist | | 10 |
| 968478494 | atomic mass unit = Dalton = amu = 1 g/mol | atomic mass unit = Dalton = amu = 1 g/mol | | 11 |
| 969857764 | fmet tRNA | N-Formylmethionine (fMet). N-Formylmethionine (fMet) is a derivative of the amino acid methionine in which a formyl group has been added to the amino group. It is specifically used for initiation of protein synthesis from bacterial and organellar genes, and may be removed post-translationally. | | 12 |
| 969857765 | BLAST e value means the chance that the sequences are the same by random chance, the smaller the e value, the less likely it is by chance, more likely they are related by a common ancestor. | BLAST e value means the chance that the sequences are the same by random chance, the smaller the e value, the less likely it is by chance, more likely they are related by a common ancestor. | | 13 |
| 969872110 | Difference between virus and virion | Virus
Any of various simple submicroscopic parasites of plants, animals, and bacteria that often cause disease and that consist essentially of a core of RNA or DNA surrounded by a protein coat. Unable to replicate without a host cell, viruses are typically not considered living organisms.
Virion
A complete viral particle, consisting of RNA or DNA surrounded by a protein shell and constituting the infective form of a virus. | | 14 |
| 969872111 | cis and trans dominant mutations | a cis dominant mutation means the mutation must be on the same chromosome as the gene to exert its effects, while a trans dominant mutation can be on a differenct chromosome | | 15 |
| 969872112 | polar mutation | A mutation that affects the transcription or translation of part of the gene or operon downstream of the mutant site. For example, nonsense mutations, frameshift mutations, and insertion sequence(IS)-induced mutations. | | 16 |
| 969872113 | imino group | a NH group not linked to any acids | | 17 |
| 969872114 | circular dichroism | a spectroscopy technique based on the observation that the absorption of light differs based on whether it is left or right circularly polarized. Can be applied to biochem because it can be used to identify helices and other secondary structures in proteins, which have unique signatures on CD | | 18 |
| 969970595 | exopeptidase | a peptidase that cleaves one residue from either the carboxyl or amino terminal end. | | 19 |
| 970849649 | microsome | In cell biology, microsomes are vesicle-like artifacts re-formed from pieces of the endoplasmic reticulum (ER) when eukaryotic cells are broken-up in the laboratory; by definition, microsomes are not ordinarily present in living cells | | 20 |
| 971029495 | 1 angrstrom = 1x10^-10m | or .1 nm | | 21 |
| 972370757 | N-terminal is first to be translated in proteins | Ditto | | 22 |
| 972385528 | remember that for er targeted proteins, translocation and translation is simultaneous, whereas for chloroplasts and mitochondria, translation occurs in the cytosol, and then the protein is kept in an unfolded state by hydrolysis of ATP and THEN translated across inner and outer membranes. | remember that for er targeted proteins, translocation and translation is simultaneous, whereas for chloroplasts and mitochondria, translation occurs in the cytosol, and then the protein is kept in an unfolded state by hydrolysis of ATP and THEN translated across inner and outer membranes. | | 23 |
| 972410351 | GPI looks like this | |  | 24 |
| 972689772 | Dynamin required to pinch off clathrin coated vesicles from membranes, is a GTPase. | COPI/COPII vesicles do not require dynamin | | 25 |
| 972696686 | Hsc70 important in removing clathrin coat following vesicle formation | heat shock protein 70 | | 26 |
| 973434020 | Initial product of C3 photosynthesis is 3-phosphoglycerate | |  | 27 |
| 973434021 | initial product of C$ photosynthesis is malate | |  | 28 |
| 973449103 | acetyl coA is used in the cytoplasm for fatty acid synthesis but formed in the mitochondria. the inner membrane of the mitochondria is impermeable to acetly coa, so it is transferred as.... | citrate |  | 29 |
| 973516255 | hyperchromicity refers to the | increase in absorbance of light of a material | | 30 |
| 973516256 | what supports endosymbiont hypothesis? | bacterial and mitochondrial ribosomes are inhibited by same drugs | | 31 |
| 973516257 | the glyoxylate cycle is lacking in animals and is responsible for | gluconeogenesis from fatty acids | | 32 |
| 973516258 | the urea cycle occurs in the | mitochondria and cytoplasm | | 33 |
| 973516259 | difference between positive strand RNA viruses and minus strand RNA viruses | positive strand RNA viruses contain mRNA that can be immediately translated into protein, while negative sense RNA viruses contain negative strand RNA which much first be converted to positive strand RNA by RNA polymerase before it can be translated. | | 34 |
| 974559758 | acid hydrolase | Any of a group of diverse hydrolytic enzymes (including
proteases, nucleases, glycosidases, etc.) that have their optimal activity at acid pH (around 5.0) and are found in lysosomes. | | 35 |
| 974559759 | acrosomal vesicle | Region at the head end of a sperm cell that contains a sac of
hydrolytic enzymes used to digest the protective coating of the egg. | | 36 |
| 974559760 | acrosome reaction | Reaction that occurs when a sperm starts to enter an egg,
in which the contents of the acrosomal vesicle are released, helping the sperm to penetrate the zona pellucida. | | 37 |
| 974559761 | activated carrier | Small diffusible molecule in cells that stores easilyexchangeable
energy in the form of one or more energy-rich covalent bonds.
Examples are ATP and NADPH. Also called a coenzyme. | | 38 |
| 974559762 | adenomatous polyposis coli (APC) | Tumor suppressor protein that forms part of a protein complex that recruits free cytoplasmic -catenin and degrades it | | 39 |
| 974559763 | affinity maturation | Progressive increase in the affinity of antibodies for the
immunizing antigen with the passage of time after immunization. | | 40 |
| 974559764 | allelic exclusion | The expression of an immunoglobulin chain (or T cell
receptor chain) gene from only one of the two homologous loci present for that gene in the lymphocyte. | | 41 |
| 974559765 | amide | Molecule containing a carbonyl group linked to an amine. | | 42 |
| 974559766 | anchorage dependence | Dependence of cell growth on attachment to a
substratum. | | 43 |
| 974559767 | animal pole | In yolky eggs, that end free of yolk that cleaves more rapidly than
the vegetal pole. | | 44 |
| 974559768 | ankyrin | Protein mainly responsible for attaching the spectrin cytoskeleton to
the red blood cell plasma membrane. | | 45 |
| 974559769 | antenna complex | Part of a photosystem that captures light energy and
channels it into the photochemical reaction center. It consists of protein complexes that bind large numbers of chlorophyll molecules and other pigments. | | 46 |
| 974559771 | ARF protein | Monomeric GTPase responsible for regulating both COPI coat
assembly and clathrin coat assembly at Golgi membranes. | | 47 |
| 974559772 | avidity | Total binding strength of a polyvalent antibody with a polyvalent antigen. | | 48 |
| 974559773 | axoneme | Bundle of microtubules and associated proteins that forms the core
of a cilium or flagellum in a eucaryotic cell and is responsible for their
movements. | | 49 |
| 974559774 | biotin | Low-molecular-weight compound used as a coenzyme. Useful
technically as a covalent label for proteins, allowing them to be detected by the
egg protein avidin, which binds extremely tightly to biotin. (2 63.) | | 50 |
| 974559775 | black membrane | Artificial planar lipid bilayer membrane. | | 51 |
| 974559776 | blastomere | One of the cells formed by the cleavage of a fertilized egg | | 52 |
| 974559777 | Ca2+/calmodulin-dependent protein kinase (CaM kinase) | Protein kinase whose activity is regulated by the binding of Ca2+-activated calmodulin (Ca2+/calmodulin), and which indirectly mediates the effects of Ca2+ by phosphorylation of other proteins. | | 53 |
| 974559779 | caged molecule | Organic molecule designed to change into an active form
when irradiated with light of a specific wavelength. An example is caged ATP | | 54 |
| 974559781 | calmodulin | Ubiquitous calcium-binding protein whose binding to other
proteins is governed by changes in intracellular Ca2+ concentration. Its binding
modifies the activity of many target enzymes and membrane transport proteins. | | 55 |
| 977212055 | capacitation | Poorly understood process that sperm must go through in the
female reproductive tract before they are competent for fertilization. | | 56 |
| 977212056 | caspase | Any of a family of intracellular proteases that are involved in
initiating the cellular events of apoptosis. | | 57 |
| 977212057 | cell cortex | Specialized layer of cytoplasm on the inner face of the plasma
membrane. In animal cells it is an actin-rich layer responsible for movements
of the cell surface. | | 58 |
| 977212058 | central lymphoid organ | (primary lymphoid organ) Lymphoid organ in
which lymphocytes develop. In adult mammals these are the thymus and bone
marrow. | | 59 |
| 977212059 | chelate | Combine reversibly, usually with high affinity, with a metal ion such
as iron, calcium, or magnesium. | | 60 |
| 977212060 | chemiosmotic coupling | Mechanism in which a gradient of hydrogen ions (a
pH gradient) across a membrane is used to drive an energy-requiring process,
such as ATP production or the rotation of bacterial flagella | | 61 |
| 977212061 | chiasma (chiasmata) | X-shaped connection visible between paired
homologous chromosomes in division I of meiosis, and which represents a site
of crossing-over | | 62 |
| 977212062 | chromaffin cell | Cell that stores adrenaline in secretory vesicles and secretes it
in times of stress when stimulated by the nervous system. | | 63 |
| 977212063 | coiled-coil | Especially stable rodlike structure in proteins which is formed by
two of these a helices coiled around each other. | | 64 |
| 977212064 | cortical granule | Specialized secretory vesicle present under the plasma
membrane of unfertilized eggs, including those of mammals; after fertilization
it is involved in preventing the entry of further sperm. | | 65 |
| 977212065 | crista (cristae) | (1) (2) One of the folds of the inner mitochondrial membrane.
(3) A sensory structure in the inner ear. | | 66 |
| 977212066 | cryptochrome | Flavoprotein responsive to blue light, found in both plants and
animals. In animals it is involved in circadian rhythms. | | 67 |
| 977212067 | dalton | Unit of molecular mass. Approximately equal to the mass of a
hydrogen atom (1.66 × 10 24 g). | | 68 |
| 977212068 | default pathway | Constitutive secretory pathway that automatically delivers
material from the Golgi apparatus to the plasma membrane if no other sorting
signals are present. | | 69 |
| 977212069 | diplotene | Fourth stage of division I of meiosis, in which chiasmata are first
seen. | | 70 |
| 977212070 | dominant negative mutation | Mutation that dominantly affects the phenotype
by means of a defective protein or RNA molecule that interferes with the function of the normal gene product in the same cell. | | 71 |
| 977212071 | filopodium (filopodia) | Thin, spike-like protrusion with an actin filament core,
generated on the leading edge of a crawling animal cell. | | 72 |
| 977212072 | fluorescein | Fluorescent dye that fluoresces green when illuminated with blue
light or ultraviolet light. | | 73 |
| 977212073 | ganglioside | Any glycolipid having one or more sialic acid residues in its
structure. Found in the plasma membrane of eucaryotic cells and especially
abundant in nerve cells. | | 74 |
| 977212074 | glutaraldehyde | Small reactive molecule with two aldehyde groups that is
often used as a cross-linking fixative. | | 75 |
| 977212075 | glycosaminoglycan (GAG) | Long, linear, highly charged polysaccharide
composed of a repeating pair of sugars, one of which is always an amino
sugar. Mainly found covalently linked to a protein core in extracellular matrix
proteoglycans. Examples include chondroitin sulfate, hyaluronic acid, and
heparin. | | 76 |
| 977212076 | helix-loop-helix (HLH) | DNA-binding structural motif present in many gene
regulatory proteins. Should not be confused with the helix-turn-helix. | | 77 |
| 977212077 | heterocaryon | Cell with two or more genetically different nuclei; produced by
the fusion of two or more different cells. | | 78 |
| 977212078 | hnRNP protein (heterogeneous nuclear ribonuclear protein | Any of a
group of proteins that assemble on newly synthesized RNA, organizing it into
a more compact form. | | 79 |
| 977212079 | Holliday junction | X-shaped structure observed in DNA undergoing
recombination, in which the two DNA molecules are held together at the site
of crossing-over, also called a cross-strand exchange. | | 80 |
| 977212080 | IAP family | Intracellular protein inhibitors of apoptosis. | | 81 |
| 977212081 | inhibitory neurotransmitter | Neurotransmitter that opens transmitter-gated
Cl or K+ channels in the postsynaptic membrane of a nerve or muscle cell
and thus tends to inhibit the generation of an action potential. | | 82 |
| 977212082 | initiation factor | Protein that promotes the proper association of ribosomes
with messenger RNA and is required for the initiation of protein synthesis. | | 83 |
| 977212083 | intercalary regeneration | Type of regeneration that fills in the missing tissues
when two mismatched parts of a structure are grafted together. | | 84 |
| 977212084 | ionophore | Small hydrophobic molecule that dissolves in lipid bilayers and
increases their permeability to specific inorganic ions. | | 85 |
| 977212085 | mating-type locus (MAT locus) | In budding yeast, the locus that determines
the mating type (a or a) of the haploid yeast cell. | | 86 |
| 977212086 | microsome | Small vesicle that is derived from fragmented endoplasmic
reticulum produced when cells are homogenized. | | 87 |
| 977212087 | midbody | Structure formed at the end of cleavage that can persist for some
time as a tether between the two daughter cells in animals. | | 88 |
| 977212088 | mismatch repair | DNA repair process that corrects mismatched nucleotides
inserted during DNA replication. A short stretch of newly synthesized DNA
including the mismatched nucleotide is removed and replaced with the correct
sequence with reference to the template strand. | | 89 |
| 977212089 | morphogen | Signal molecule that can impose a pattern on a field of cells by
causing cells in different places to adopt different fates. | | 90 |
| 977212090 | Nernst equation | Quantitative expression that relates the equilibrium ratio of
concentrations of an ion on either side of a permeable membrane to the voltage
difference across the membrane. (See Panel 11 2, p. 634.) | | 91 |
| 977212091 | nonsense-mediated mRNA decay | Mechanism for removing aberrant mRNAs
containing in-frame internal stop codons before they can be translated | | 92 |
| 977212092 | Notch | Receptor protein involved in many instances of choice of cell fate in
animal development, for example in the specification of nerve cells from
ectodermal epithelium. Its ligands are cell-surface proteins such as Delta and
Serrate. | | 93 |
| 977212093 | occluding junction | Type of cell junction that seals cells together in an
epithelium, forming a barrier through which even small molecules cannot pass. | | 94 |
| 977212094 | phragmoplast | Structure made of microtubules and actin filaments that forms
in the prospective plane of division of a plant cell and guides formation of the
cell plate. | | 95 |
| 977212095 | primosome | A complex of DNA primase and DNA helicase that is formed on
the lagging strand during DNA replication, improving the efficiency of
replication. | | 96 |
| 977212096 | quinone (Q) | Small, lipid soluble, mobile electron carrier molecule found in
the respiratory and photosynthetic electron-transport chains. | | 97 |
| 977212097 | rhodopsin | G-protein-linked light-sensitive receptor protein in the rod
photoreceptor cells of the retina. | | 98 |
| 977212098 | synteny | The presence in different species of regions of chromosomes with the
same genes in the same order. | | 99 |
| 977212099 | survival factor | Extracellular signal required for a cell to survive; in its
absence the cell will undergo apoptosis and die. | | 100 |
| 977212100 | stereocilium | A large, rigid microvillus found in "organ pipe" arrays on the
apical surface of hair cells in the ear. A stereocilium contains a bundle of actin
filaments, rather than microtubules, and is thus not a true cilium. | | 101 |
| 977212101 | spectrin | Abundant protein associated with the cytosolic side of the plasma
membrane in red blood cells, forming a rigid network that supports the
membrane. | | 102 |
| 977212102 | V gene segment | Gene segment encoding most of the variable region of the
polypeptide chains of immunoglobulins and T cell receptors. | | 103 |
| 977212103 | vegetal pole | The end at which most of the yolk is located in an animal egg.
The end opposite the animal pole. | | 104 |
| 977212104 | zona pellucida | Glycoprotein layer on the surface of the unfertilized egg. It is
often a barrier to fertilization across species. | | 105 |
| 977333492 | cryptochrome | are a class of blue light-sensitive flavoproteins found in plants and animals. Cryptochromes are involved in the circadian rhythms of plants and animals, and in the sensing of magnetic fields in a number of species | | 106 |
| 978785264 | Stereoisomers | same chemical bonds, different stereochemistry | | 107 |
| 978785265 | Enantiomers | mirror image stereoisomers | | 108 |
| 978785266 | Diastereomers | stereoisomers that are not mirror images | | 109 |
| 978785267 | solvation layer | shell of water around a hydrophobic molecule | | 110 |
| 978785268 | competitive enzyme inhibition | binds active site, blocking catalysis
o Vmax same, Km increases (plots cross) | | 111 |
| 978785269 | uncompetitive inhibition | un-competitive inhibition - bind to E5 complex at separate site
o Vmax & Km lowered (plots parallel) | | 112 |
| 978785270 | mixed inhibition | binds alternative site wi or wlo substrate
o effects both V max & Km | | 113 |
| 978785271 | noncompetitive inhibition | very unusual
. 0 Vmax lowered, Km same (plots cross) | | 114 |
| 978785272 | adjacent bases are separated by 3.4 angstroms and 36 degrees of rotation, therefore the helix structure repeats itself after 10 bases and 34 angrstroms (3.4nm) | adjacent bases are separated by 3.4 angstroms and 36 degrees of rotation, therefore the helix structure repeats itself after 10 bases and 34 angrstroms (3.4nm) | | 115 |
| 981775194 | elastase | protease cuts after small hydrophobic aa's breaks down elastin, collagen | | 116 |
| 981775195 | trypsin | cut carboxyl of lysine or arginine (positive charged) | | 117 |
| 981775196 | chymotrypsin | interesting - synthesized as chymotrypsinogen which is then hydrolzed into two parts which can auto activate each other. cuts after large hydrophobic (aromatic) | | 118 |
| 981775197 | scissile bond | covalent chemical bond that can be broken by an enzyem | | 119 |
| 981775198 | urea(ornithine) cycle takes place | almost all in liver | | 120 |
| 981775199 | calmodulin | is a calcium-binding messenger protein expressed in all eukaryotic cells. CaM is a multifunctional intermediate messenger protein that transduces calcium signals by binding calcium ions and then modifying its interactions with various target proteins.[1] | | 121 |
| 982424532 | protamine | packing material of DNA in sperm cels (instead of histones). allow for tighter packing of DNA, rich in arginine (positive charges). 10-15% in sperm still packed with histones (used for earyl development) | | 122 |
| 983485304 | capacitation of sperm | occurs in the vagina in repsonse to HCO3-, which activates a solubley andenyly cyclase in sperm cells | | 123 |
| 983485305 | Gibbs-Donnan effect | is a name for the behavior of charged particles near a semi-permeable membrane that sometimes fail to distribute evenly across the two sides of the membrane.[1] The usual cause is the presence of a different charged substance that is unable to pass through the membrane and thus creates an uneven electrical charge.[2] For example, the large anionic proteins in blood plasma are not permeable to capillary walls. Because small cations are attracted, but are not bound to the proteins, small anions will cross capillary walls away from the anionic proteins more readily than small cations. | | 124 |
| 983485306 | C0t analysis | a technique based on the principles of DNA reassociation kinetics, is a biochemical technique that measures how much repetitive DNA is in a DNA sample such as a genome.[1] It is used to study genome structure and organization and has also been used to simplify the sequencing of genomes that contain large amounts of repetitive sequence.[2]
ContentsSince a sequence of single-stranded DNA needs to find its complementary strand to reform a double helix, common sequences renature more rapidly than rare sequences. Indeed, the rate at which a sequence will reassociate is proportional to the number of copies of that sequence in the DNA sample. A sample with a highly-repetitive sequence will renature rapidly, while complex sequences will renature slowly. |  | 125 |
| 983493193 | Epistasis | a phenomenon in which the expression of one gene depends on the presence of one or more 'modifier genes'. A gene whose phenotype is expressed is called epistatic, while one whose phenotype is altered or suppressed is called hypostatic. If two epistatic genes A and B are mutated, and each mutation by itself produces a unique phenotype but the two mutations together show the same phenotype as the gene A mutation, then gene A is epistatic to gene B. | | 126 |
| 983493194 | Maternal effect | A maternal effect is a situation where the phenotype of an organism is determined not only by the environment it experiences and its genotype, but also by the environment and genotype of its mother. In genetics, maternal effects occur when an organism shows the phenotype expected from the genotype of the mother, irrespective of its own genotype, often due to the mother supplying mRNA or proteins to the egg. Maternal effects can also be caused by the maternal environment independent of genotype, sometimes controlling the size, sex, or behaviour of the offspring. These adaptive maternal effects lead to phenotypes of offspring that increase their fitness. Further, it introduces the concept of phenotypic plasticity, an important evolutionary concept. It has been proposed that maternal effects are important for the evolution of adaptive responses to environmental heterogeneity. | | 127 |
| 983493195 | gastrin | is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility | | 128 |
| 984081098 | blue white screen | The blue-white screen is a screening technique that allows for the rapid and convenient detection of recombinant bacteria in vector-based molecular cloning experiments. DNA of interest is ligated into a vector. The vector is then transformed into competent cell (bacteria), and the competent cells are grown in the presence of X-gal. Cells transformed with vectors containing recombinant DNA will produce white colonies; cells transformed with non-recombinant plasmids (i.e. only the vector) grow into blue colonies. | | 129 |
