DNA Repair Mechanisms
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Senescence
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Molecular Bionumbers Notes
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Useful fundamental numbers in molecular biology The numbers quoted here were extracted from the literature. They should only serve as ?rule of thumb? values. Consult the full references to learn about the specific system under study, growth conditions, measurement method etc. Full references at: www.bioNumbers.org Cell sizes: Bacteria (e.coli): ~1mm diameter, 2mm length, ~1mm3 in volume; 109cells/ml in an overnight culture (OD600~1) Yeast (Saccharomyces cerevisiae): ~5 mm diameter, ~50 mm3 in volume Mammalian (HELA) cell - ~2,000 mm3 in volume, adherent cell on a slide ~20 mm diameter ? ~100,000 cells in a confluent well of a 96 multiwell plate Organelles and cell constituents: Mammalian cell nucleus ~10 micron diameter
Biology Genetic Concepts
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Holandric ? Genes found on the Y- Chromosome Teratogens ? agents of nature that cause abnormalities in the foetus Polytene chromosomes ? chromosomes that successively replicate without any cell division making ?chunk?. Oncogene ? gene that under high temperature and mutation turn a normal cell in to a cancer cell, such as a tumor cell. Histones ? a protein that shortens the long DNA molecule so that all the DNA molecules can fit inside the nucleus. Totipotency- the ability of a cell to reactivate all the genes in a genome. Chromosomal puffs ? indicate a region where DNA replication is taking place. Supercoiling ? is the coiling of DNA. It reduces the space and allows for a lot more DNA to be packaged.
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