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Botkin and Keller Chapter 15 Reading Guide

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APES- Chapter #15: Environmental Health, Pollution and Toxicology Name: __________________________________________________ Learning Objectives: Serious environmental health problems and diseases may arise from toxic elements in water, air, soil, and even the rocks on which we build our homes. After reading this chapter, you should understand: How the terms toxic, pollution, contamination, carcinogen, synergism, and biomagnifications are used in environmental health What the classification and characteristics are of major groups of pollutants of environmental toxicology Why there is controversy and concern about synthetic organic compounds such as dioxin Whether we should be concerned about exposure to human-produced electromagnetic fields

Botkin and Keller Chapter 10 Reading Guide

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APES- Chapter #10: Environmental Health, Pollution and Toxicology Name: __________________________________________________ Learning Objectives: Serious environmental health problems and diseases may arise from toxic elements in water, air, soil, and even the rocks on which we build our homes. After reading this chapter, you should understand: ? How the terms toxic, pollution, contamination, carcinogen, synergism, and biomagnifications are used in environmental health ? What the classification and characteristics are of major groups of pollutants of environmental toxicology ? Why there is controversy and concern about synthetic organic compounds such as dioxin ? Whether we should be concerned about exposure to human-produced electromagnetic fields ?

Anatomy circulatory system

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Arteries Take blood from heart to capillaries Elastic arteries vs muscular arteries Arteriesarterioles capillaries Artery take to get anywhere you need to
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Cell bio chapter 6

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Cells Use molecules to: Transform energy and matter Respond to the environment Reproduce themselves Lowest level that can perform all activities required for life Cell theory Cells are the fundamental units of life All organisms are composed of cells All cells are going to be derived from preexisting cells Are similar in chemical composition Concept 6.1 Microscopes and the Tools of Biochemistry are used to Study Cells Magnification: ratio of image size to real size Resolution: measure of clarity What is the minimum distance required to distinguish two points as separate Light microscopy View living cells Magnify 2000X Resolution: 200nm Electron microscopes View dead cells Magnify 2,000,000X Resolution 0.2 nm Scanning electron microscopy Surface of a specimen (3D)

Cell bio chapter 4/5

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Substances found in living tissues Water, macromolecules, proteins, nucleic acids, carbs Concept 4.3 Functional groups Components of organic molecules Involved in chemical reactions Give molecules unique properties Functional groups important in chemistry of life Hydroxyl group, carbonyl group, amino group, carboxyl group Functional groups of sex hormones Functional groups give each molecule unique properties Phosphate group Nucleic acids Adenosine triphosphate (ATP) Concept 4.2 Isomers- compounds with same molecular formula, but different structures and properties Dif shape dif biological abilities Structural isomers- different covalent arrangements of atoms Enantiomers- mirror images of each other Even subtle differences can have different biological response

Cell bio chapter 11

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Concept 11.1 Local Signaling Cells may communicate by direct contact Animal cells Gap junctions Cell junctions Plant cells Plasmodesmata between cell plants Signaling substances can pass freely between adjacent cells Cell?cell recognition Paracrine signaling Short distances One cell can secrete some chemical or molecule that can then act on neighboring cells Example growth factors Stimulate adjacent cells to grow and divide Synaptic signaling Nerve cells in brain from one cell to another mostly an electrical signal Electrical signal triggers release of neurotransmitter Long distance signaling Endocrine signaling Hormones travels in bloodstream Target cell specifically binds hormone 3 stages of cell signaling 1 reception signaling molecule will combine to receptor

Cell bio chapter 7

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Two types of membrane proteins Integral proteins and peripheral proteins Trans membrane protein structure Alpha helix from hydrogen bonds Functions of membrane proteins Transport- one with ATP one without it Enzymes- catalyze biochemical reactions; enzymatic activity Signal transduction Cell-cell recognition- how can a cell determine if the cell is of like kind or like species Intercellular joining- cells adhering to each other to form tissues and then organs when proteins join together Attachment- attach to cellular matrix to form an organ Cell adhesion and Recognition Cells bind to surface molecules on the plasma membrane Carbohydrates vary among Species Individuals Cell types Synthesis of membrane components Glycolipids Glycoproteins

Regulation of the cell cycle

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Cell Cycle Regulation Cell cycle control systems The frequency of cell division varies with the type of cell Caused by the difference in regulation at the molecular level The stages of the cell cycle are regulated by a distinct cell cycle control system (similar to a clock) The cell cycle control system is regulated by both internal and external controls The clock has specific checkpoints where the cell cycle stops until a go-ahead signal is received Cell cycle control systems: interphase and mitosis Interphase Makes up about 90% of the cell cycle: can be divided into subphases: G1 phase (?first gap?) S phase (?synthesis?) G2 phase (?second gap?) The cell grows during all three phases Chromosomes are only duplicated during the S phase

Cell Membranes

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Cell Membranes Contents: Structure: the basics Fluid mosaic model/freeze fracture technique Membrane fluidity Membrane fluidity and cholesterol The Basics? The plasma membrane separates the living cell from its surroundings Phospholipids make up the majority of the bilayer Phospholipids consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails Phospholipids are amphipathic molecules: containing both a hydrophilic and hydrophobic region The plasma membrane is described by the fluid mosaic model: The membrane is fluid with a variety of ?mosaic? proteins embedded in it The plasma membrane is selectively permeable: Small fat soluble (hydrophobic ? non polar) molecules, can enter the cell through the lipid bilayer (this occurs rapidly) e.g. hydrocarbons

The Cytoskeleton

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The Cytoskeleton The cytoskeleton extends throughout the cytoplasm It organises cell structure and activities, anchoring many organelles in place It provides mechanical support, maintaining the cells shape: it?s domed in shape and stabilised by opposing forces It is also very dynamic, and can be dismantled and reassembled quickly, to change the shape of the cell Form The cytoskeleton is a network of fibres, the molecular structures include: Microtubules: the thickest of the fibres at 25nm (15nm lumen) Microfilaments: the thinnest of the fibres at 7nm Intermediate filaments: range in diameter from 8?12nm, larger than microfilaments but smaller than microtubules Roles

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